Experimental models of systemic autoimmunity have been developed in rats and mice using mercurials, gold salts or dpenicillamine, all known to induce various autoimmune disorders in exposed. First identified in mice in 2011, a subset of b cells that expands with. Sometimes the immune system makes a mistake and starts attacking the bodys own tissues or organs. Autoimmune diseases as a group impose a major burden on our nations health. Robert w hostoffer, do, lhd, facop, fccp, facoi hospitals. Virtually all are debilitating, and require lifelong medical care. While most of these diseases are individually rare, in the aggr egate they affect between five and eight percent of americans. Autoimmunity is the system of immune responses of an organism against its own healthy cells and tissues. Report of the autoimmune diseases coordinating committee. Autoimmunity is characterized by the reaction of cells auto reactive tlymphocytes or products autoantibodies of the immune system against the organisms own antigens autoantigen. It is a complex genetic disorder, and hla status appears to be the strongest genetic determinant of risk for celiac autoimmunity. Gluten is a complex molecule made of gliadin and glutenins, both toxic for cd patients. For example, an immune response to a virus can cause damage to the heart called myocarditis.
Human autoimmune diseases ad occur frequently affecting in aggregate more than 5% of the population worldwide, and impose a significant burden of morbidity and mortality on the human population. This can make it confusing when considering if fibromyalgia is an autoimmune disease. It is believed that enhanced research in this area holds the potential to cure and prevent many diseases. Any disease that results from such an aberrant immune response is. Some other common autoimmune disorders include rheumatoid arthritis, systemic lupus erythematosus lupus, and vasculitis. In addition, several diseases are related to autoimmunity or caused by an autoimmune disease but are not themselves autoimmune diseases. Autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, diabetes, and lupus affect millions of americans and disproportionately affect women and minorities.
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